Grooming
The French Spaniel needs more grooming, brushing a few times a week, where the German Shorthaired Pointer needs a brush once a week.
Temperament
They differ most on affection (French Spaniel: affectionate on its own terms; German Shorthaired Pointer: a lap or leaning dog) and on independence (French Spaniel: keen to work with you; German Shorthaired Pointer: cooperative, with its own ideas).
Alike
They are much the same size as adults, about 25 kg (55 lb) for the French Spaniel and 26 kg (57 lb) for the German Shorthaired Pointer.