Lifespan
In UK vet records the Rottweiler lives longer: a median of 10.6 years, against 8.1 for the Cane Corso.
Shedding
Their coats shed differently: the Cane Corso sheds through the year, the Rottweiler moults most as the seasons change.
Grooming
The Rottweiler needs more grooming, brushing a few times a week, where the Cane Corso needs a brush once a week.
Temperament
They differ most on affection (Cane Corso: affectionate on its own terms; Rottweiler: a lap or leaning dog) and on sensitivity (Cane Corso: average; Rottweiler: hardy, takes a busy home in its stride).
Alike
The Cane Corso and the Rottweiler are much the same size as adults, both about 45 kg (99 lb).
Alike
Both are rated the same on loyalty: sticks close to its people.