Lifespan
In UK vet records the Great Dane lives longer: a median of 10.6 years, against 9.3 for the Saint Bernard.
Shedding
Their coats shed differently: the Great Dane sheds through the year, the Saint Bernard moults most as the seasons change.
Temperament
They differ most on sensitivity (Great Dane: average; Saint Bernard: hardy, takes a busy home in its stride) and on prey drive (Great Dane: chases; needs managing; Saint Bernard: usually fine with small pets).
Alike
They are much the same size as adults, about 64 kg (141 lb) for the Great Dane and 66 kg (145 lb) for the Saint Bernard.
Alike
Both are rated the same on affection: a lap or leaning dog.