Lifespan
In UK vet records the Great Pyrenees lives longer: a median of 10.9 years, against 9.3 for the Saint Bernard.
Exercise
Plan for a moderate amount of exercise with the Saint Bernard, and a modest amount with the Great Pyrenees.
Temperament
They differ most on voice (Great Pyrenees: very vocal; Saint Bernard: quiet) and on affection (Great Pyrenees: affectionate on its own terms; Saint Bernard: a lap or leaning dog).
Alike
They are much the same size as adults, about 65 kg (143 lb) for the Great Pyrenees and 66 kg (145 lb) for the Saint Bernard.
Alike
Both are rated the same on sensitivity: hardy, takes a busy home in its stride.