Shedding
Their coats shed differently: the Saint Bernard moults most as the seasons change, the Tosa sheds through the year.
Temperament
They differ most on affection (Saint Bernard: a lap or leaning dog; Tosa: likes its own space) and on independence (Saint Bernard: cooperative, with its own ideas; Tosa: decides for itself).
Alike
They are much the same size as adults, about 66 kg (145 lb) for the Saint Bernard and 61 kg (135 lb) for the Tosa.
Alike
Both are rated the same on intelligence: easy-going, simple routines.